Applied_Meta－Analysis_with_R.pdf本书详细地介绍了如何用R语言进行me

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详细说明：本书详细地介绍了如何用R语言进行meta分析，讲解全面细致并附上代码Chapman Hall/CRC Biostatistics Series Editor-in-Chief Shein-Chung Chow, Ph D Professe Department of Biostatistics and Bioinformatics Duke University School of Medicine Durham north carolina Series Editors Byron Jones Jen-pei Liu Biometrical fellow Professor Statistical Methodology Division of Biometry Integrated Information Sciences Department of Agronomy Novartis pharma ag National Taiwan University Taipei, Taiwan Basel switzerland KarE。 Peace Bruce w turnbull Georgia cancer Coalition Professor Distinguished Cancer Scholar School of Operations Research Senior research Scientist and and Industrial Engineering Professor of biostatistics Cornell niversity Jiann-Ping Hsu College of Public Health Ithaca. New York Georgia Southern University Statesboro, georgia K14600 FM indd 4/3/131:27PM Chapman hall/ CRC Biostatistics Series Adaptive Design Methods in Clinical Trial Data Analysis using R Clinical trials, Second edition Ding-Geng(Din) Chen and Karl EPeace Shein-Chung Chow and Mark Chang Clinical Trial Methodology Adaptive Design Theory and Karl E Peace and Ding-Geng(Din) Cher Implementation Using SAS and R Computational Methods in Biomedical Mark Chang Research Advanced Bayesian Methods for Medical Ravindra Khattree and Dayanand N Naik Test Accuracy Computational Pharmacokinetics Lyle D. Broemeling Anders Kallen Advances in Clinical Trial Biostatistics Confidence Intervals for Proportions and Nancy L Geller Related measures of effect size Applied Meta-Analysis with R Robert G. Newcombe Ding-Geng(Din) Chen and Karl E Peace Controversial statistical issues in Basic statistics and pharmaceutical Clinical Trials Statistical Applications, Second Edition Shein-Chung Chow James e de muth Data and safety monitoring committees Bayesian Adaptive Methods for in Clinical trials Clinical trials Jay Herson Scott M. Berry, Bradley P. Carlin Design and Analysis of Animal Studies in J. Jack Lee and Peter Muller Pharmaceutical Development Bayesian Analysis Made Simple: An Excel Shein-Chung Chow and Jen-pei Liu GUI for win BUGS Design and Analysis of Bioavailability and Phil woodward inequivalence Studies, Third Edition Bayesian Methods for Measures of Shein-Chung Chow and Jen-pei Liu Agreement Design and Analysis of Bridging Studies Lyle D. Broemeling Jen-pei Liu, Shein-Chung Chow, Bayesian Methods in health Economics and chin-Fu hsiao Gianluca baio Design and Analysis of clinical Trials with Bayesian Missing Data Problems: EM Time-to-Event Endpoints Data Augmentation and noniterative Karl e. Peace Computation Design and Analysis of Non-Inferiority Ming T. Tan, Guo-Liang Tian Trials and Kai Wang Ng Mark d, rothmann brian l. wiens Bayesian Modeling in Bioinformatics and lvan S f chan Dipak K Dey samiran ghosh Difference Equations with Public Health and bani K. mallick Applications Biostatistics: A Computing Approach emuel A Moye and asha seth Kapadia Stewart J Anderson DNA Methylation Microarrays. Causal Analysis in Biomedicine and Experimental Design and Statistical Epidemiology: Based on Minimal Analysis Sufficient Causation Sun-Chong Wang and arturas petronis Mikel Aickin K14600 FM indd 3 4/3/131:27PM DNA Microarrays and related Genomics Multiple Testing Problems in Techniques: Design, Analysis, and Pharmaceutical statistics Interpretation of Experiments Alex Dmitrienko, Ajit C. Tamhane David B. Allison. Grier P Page and frank bretz T Mark beasley and jode w. edwards Randomized clinical trials of Dose Finding by the continua Nonpharmacological Treatments Reassessment method Isabelle Boutron, Philippe Ravaud, and Ying Kuen Cheung David moher Elementary Bayesian Biostatistics Randomized phase ll cancer clinical Lemuel A Moye Trials Frailty Models in Survival Analysis Sin-Ho Jung Andreas Wienke Sample Size Calculations in Clinical Generalized Linear Models: a bayesian Research, Second edition Perspective Shein-Chung Chow, Jun Shao Dipak K Dey, Sujit K. Ghosh, and Hansheng Wang and bani K. mallick Statistical Design and Analysis of Handbook of Regression and Modeling: Stability Studies Applications for the clinical and Shein-Chung chow Pharmaceutical Industries Statistical Evaluation of Diagnostic Daryl S Paulson Performance: Topics in ROC Analysis Interval-Censored Time-to-Event Data: Kelly H. Zou, Aiy Liu, Andriy Bandos, Methods and Applications Lucila ohno-Machado, and howard rockette Ding-Geng(Din) Chen, Jianguo Sun, Statistical methods for clinical trials and Karl e. Peace Mark x. orleans Joint Models for Longitudinal and time Statistics in Drug Research: to-Event Data: With Applications in R Methodologies and Recent Dimitris rizopoulos Developments Measures of Interobserver Agreement Shein -Chung Chow and Jun Shao and reliability second edition Statistics in the Pharmaceutical Industry Mohamed m. shoukri Third edition Medical biostatistics, Third edition Ralph Buncher and Jia-Yeong Tsay A Indrayan Translational Medicine: Strategies and Meta-Analysis in Medicine and Health Statistical methods Policy Dennis cosmatos and shein -Chung chow Dalene Stangl and donald A Berry Monte carlo simulation for the Pharmaceutical Industry: Concepts, Algorithms, and case studies Mark Chang K14600 FM indd 4 4/3/131:27PM Chapman hall/crc Biostatistics Series Applied Meta-Analysis with R Ding-Geng(Din) chen Karl e peace CRC) CRC Press Boca Raton London New york CRC Press is an imprint of the Taylor Fr nforma b a chapman hall book K14600 FM indd 5 4/3/131:27PM CRC Press Taylor Francis Group 6000 Broken Sound Parkway NW, Suite 300 Boca raton fl 334 87-2742 o 2013 by Taylor Francis Group, LLC CRC Press is an imprint of Taylor Francis Group, an Informa business No claim to original U.S. Government works Version date: 20130403 International Standard Book Number-13: 978-1-4665-0600-8(eBook -PDF This book contains information obtained from authentic and highly regarded sources. Reasonable efforts have been made to publish reliable data and information, but the author and publisher cannot assume responsibility for the validity of all materials or the consequences of their use. The authors and publishers have attempted to trace the copyright holders of all material reproduced in this publication and apologize to copyright holders if permission to publish in this form has not been obtained. If any copyright material has not been acknowledged please write and let us know so we may rectify in any future reprint Except as permitted under U.S. Copyright Law, no part of this book may be reprinted, reproduced, transmitted, or utilized in any form by any electronic, mechanical, or other means, now known or hereafter invented, including photocopying, microfilming, and recording, or in any information stor- age or retrieval system, without written permission from the publishers Forpermissiontophotocopyorusematerialelectronicallyfromthisworkpleaseaccesswww.copy- rightcom(http://www.copyright.com/)orcontacttheCopyrightClearanceCenter,iNc.(ccc),222 Rosewood Drive, Danvers, MA 01923, 978-750-8400. CCC is a not-for-profit organization that pro vides licenses and registration for a variety of users. For organizations that have been granted a pho- tocopy license by the CCC, a separate system of payment has been arranged Trademark Notice: Product or corporate names may be trademarks or registered trademarks, and are used only for identification and explanation without intent to infringe Visit the Taylor francis Web site at http://www.taylorandfrancis.com and the crc press Web site at http://www.crcpress.com To my parents and parents-in-law who value higher education and hard work. and to inly wife, Ke, Inly sOIl, JohI D. CheIl, and ly daughter, Jellnly K. Chen for their love and support Ding-Geng(Din)Chen To the memory of my late mother, Elsie Mae Cloud Peace, my late wife Jiann-Ping Hsu, and to my son, Christopher K. Pcacc, daughtcr-in-law, Ashley Hopkins Pcacc, and grandchildren, Camden and Henry Karl e. peace Contents List of Figures List of tables XIX Preface 1 Introduction to r 1.1 What is R 1 1.2 Steps for Installing R and Updating R Packages 1.2.1 First Step: InstallR Base system 1. 2.2 Sccond Stcp: Installing and Updating R Packages 1.2.3 Steps to Get Ilelp and Documentation 3457 1. 3 Database Management and Data Manipulations 1.3.1 RMySQL to Microsoft Excel 3.2 Other Methods to read data into r 789 1.3.3 R Package forei 1. 4 A Simple simulation on Multi-Center Studies 10 1.4.1 Data Simulati lon 1.4.1. R Functions 10 1.4.1.2 Data Generation and manipulatiOn 1.4.1.3 Basic R graphics 16 1.4.2 Data Analysis 21 1.4.2.1 Data Analysis from Each Center 21 1.4.2. 2 Data Analysis with Pooled Data from five Centers 23 1.4.2.3 A Brief Introduction to Met a-analysis 24 1.5 Summary and Recommendations for Further Reading 2 Research Protocol for Meta-Analyses 31 2.1 Introduction 31 2. 2 DefilliIly the Research Ob 32 2.3 Criteria for Identifying Studies to Include in the Meta-Analysis 33 2.3.1 Clarifying the Disease under Study 33 2.3.2 The Effectiveness measure or Outcome 34 2.3.3 The Type of Control Group 2.3. 4 Study Characteristics 2.3.5 Type of patient. 2.3.6 Length of Study 3 2.4 Searching for and Collecting the Studies 36 2.5 Data Abstraction and Extraction 38 2.6 Meta-Analysis Methods 40 2.7 Results 2.8 Summary and discussion 41 3 Fixed-Effects and Random-Effects in Meta-analysis 43 3.1 Two Datasets from Clinical Studies 44 3.1.1 Data for Cochrane Collaboration Logo: Binary Data. 44 1.2 Clinical Studies on Amlodipine: Continuous Data 45 3.2 Fixed-Effects and Random-Effects Models in Meta-Analysis. 45 3.2.1 Hypotheses and Effect Size 46 3.2.2 Fixed-Effects Meta-Analysis Model: The Weighted A 3.2.2.1 Fixcd- Effccts modcl 3.2.2.2 The Weighting Schemes 3.2.3 Random-Effects Meta-Analysis Model: DerSimonian 50 3.2.3.1 Random-Effects Model 3.2.3.2 Derivation of DerSimonian-Laird Estimator of 5 3.2.4 Publication b 54 3.3 Data Analysis in R 3.3.1 Meta-Analysis for Cochrane Collaboration Logo 3.3.1.1 Fitting the Fixed-Effects model

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